Selective Estrogen Receptor Degrader LX-039

**Semantic type:** Pharmacologic Substance

**Definition:** An orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, SERD LX-039 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that results in ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.

**Synonyms:** - LX 039 - LX-039 - LX039 - SERD LX-039