Fluorine F 18 Flotufolastat Gallium

**Semantic type:** Pharmacologic Substance

**Definition:** A radiohybrid prostate specific membrane antigen (rhPSMA) ligand, rhPSMA-7.3, labeled, via the bifunctional, macrocyclic chelating agent 1,4,7,10-tetraazacyclododecane-1-(glutamic acid)-4,7,10-triacetic acid (DOTAGA; DOTA-GA) in complex with nonradioactive gallium, with the radioisotope fluorine F 18, which is covalently bound to silicon, with potential imaging activity using positron emission tomography/computed tomography (PET/CT) or positron emission tomography/magnetic resonance imaging (PET/MRI). Upon administration of fluorine F 18 flotufolastat gallium, the rhPSMA-7.3 moiety targets and binds to PSMA-expressing tumor cells. This allows for visualization of PSMA-expressing cells upon imaging. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and strongly overexpressed in prostate cancer (PCa) cells, with its level rising with increasing tumor differentiation and in hormone-refractory cancers.

**Synonyms:** - (18F)-rhPSMA-7.3 - 18F-rhPSMA-7.3 - 18FrhPSMA-7.3 - F-18-rhPSMA-7.3 - FLOTUFOLASTAT F-18 GALLIUM - Fluorine F 18 Radiohybrid PSMA-7.3 - Fluorine F 18 rhPSMA-7.3 - Fluorine-18 rhPSMA-7.3 - Posluma - Posluma - rhPSMA-7.3 (18F)