GATA2/MECOM Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal rearrangement either t(3;3)(q21;q26) or inv(3)(q21q26) which fuses the promoter sequences from the GATA2 gene on either the 5' or 3' side of the coding sequence of the MECOM gene. This rearrangement is associated with overexpression of the histone-lysine N-methyltransferase MECOM protein and 3q21q26 syndrome-related leukemias.

**Synonyms:** - GATA2-MECOM Fusion Gene - GATA2::MECOM Fusion Gene - RPN1/MECOM Fusion Gene - RPN1/MECOM Fusion Gene