Oncogene MYB

**Semantic type:** Gene or Genome

**Definition:** Human Oncogene MYB is a mutated variant of MYB Gene, which encodes 6 alternative isoforms of 640 aa 72-kDa nuclear c-MYB protein, a DNA-binding transcriptional activator critical for hematopoietic progenitor cell proliferation and differentiation. MYB contains 3 N-terminal MYB-like DNA-binding domains that specifically recognize YAAC[GT]G, a central transcriptional activation domain and a C-terminal transcriptional repression domain. MYB may interact with HIPK2 and NLK; phosphorylation by NLK on multiple sites may induce proteasomal degradation. Ubiquitination may be mediated by SIAH1. Oncogene MYB disrupts normal cell function.

**Synonyms:** - Avian Myeloblastosis Viral (v-MYB) Oncogene Homolog - MYB - Oncogene AMV - v-MYB Avian Myeloblastosis Viral Oncogene Homolog