Plitidepsin

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth.

**Synonyms:** - APLD - Aplidin - Aplidine - Aplidine - DDB - Dehydrodemnin B - Dehydrodidemnin B - N-[1-(1,2-Dioxopropyl)-L-prolyl]didemnin A - PLITIDEPSIN - aplidine