Gastrin Immunotoxin

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** An immunotoxin containing an epitope of human gastrin conjugated to diphtheria toxin, with antineoplastic activity. The gastrin epitope in this vaccine is chemically identical or similar to the endogenous gastrin-17 (G-17), a 17-amino acid peptide hormone that stimulates secretion of gastric acid by the stomach. Diphtheria toxin inhibits protein synthesis via modifying translation elongation factor 2 (EF-2). Vaccination with this immunotoxin may elicit production of antibodies against gastrinoma cells overexpressing gastrin, in addition to the toxic effects on protein synthesis exerted by the diphtheria toxin moiety.

**Synonyms:** - Anti-Gastrin Therapeutic Vaccine - Anti-gastrin 17 - G17DT - G17DT IMMUNOGEN - G17DT Immunogen - Gastrimmune - Neutralize Hormone G17 - Neutralizing G17 Hormone