Custirsen

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A mixed-backbone antisense oligodeoxynucleotide, with potential chemosensitizing activity. Upon administration, custirsen prevents the translation of testosterone-repressed prostate message-2 (TRPM-2). This abrogates the anti-apoptotic effect of TRPM-2, thereby sensitizing cells to chemotherapy and resulting in tumor cell death. TRPM-2 is an anti-apoptotic clusterin that is overexpressed by prostate cancer cells and is associated with chemoresistance.

**Synonyms:** - CUSTIRSEN