Obexelimab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A humanized immunoglobulin G1 (IgG1) noncytolytic monoclonal antibody directed against the B-cell-specific cell surface antigen CD-19, Fc-engineered for increased affinity to Fc gamma receptor IIB (FcgRIIB; CD32B), with potential immunomodulatory activity. Upon administration, obexelimab simultaneously targets and binds to both CD19 and FcgRIIB expressed on the surface of B-cells, and inhibits B-cell receptor (BCR) signaling and the activity of B-cells without depleting the B-cells. This may alleviate manifestations of autoimmune diseases including systemic lupus erythematosus (SLE). CD19 and FcgRIIB, both expressed on the surface of B-cells, play important roles in BCR signaling, and B-cell activity and survival.

**Synonyms:** - OBEXELIMAB - XMAB 5871 - XMAB-5871 - XMAB5871 - ZB 012 - ZB-012 - ZB012