Pegloprastide

**Semantic type:** Indicator, Reagent, or Diagnostic Aid|Pharmacologic Substance

**Definition:** A protease-cleavable peptide linked to a fluorescent probe, with potential imaging activity. Upon intravenous infusion of pegloprastidebefore surgery, the peptide moiety of AVB-620 can be cleaved by proteases overexpressed by tumor cells. This activates the fluorescent probe and the tumor cells expressing the prote ases can be detected using a fluorescence imaging system. This allows for the visualization and removal of the tumor during surgery.

**Synonyms:** - AVB-620 - Fluorescent Protease-activated Peptide AVB-620 - PEGLOPRASTIDE