Voriconazole

**Semantic type:** Antibiotic|Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic triazole with antifungal activity. Voriconazole selectively inhibits 14-alpha-lanosterol demethylation in fungi, preventing the production of ergosterol, an essential constituent of the fungal cell membrane, and resulting in fungal cell lysis. (NCI04)

**Synonyms:** - (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol - VORICONAZOLE - Vfend - voriconazole