SDF-1 Receptor Antagonist PTX-9908

**Semantic type:** Pharmacologic Substance

**Definition:** A stromal cell-derived factor 1 (SDF-1; CXCL12) analog and inhibitor of C-X-C chemokine receptor type 4 (CXCR4), with potential antineoplastic activity. Upon administration, PTX-9908 selectively targets and binds to CXCR4, thereby preventing the binding of CXCR4 to its ligand SDF-1. This inhibits receptor activation and results in decreased proliferation and migration of CXCR4-overexpressing tumor cells. The G protein-coupled receptor CXCR4, which is overexpressed in several tumor cell types, promotes tumor angiogenesis, tumor cell proliferation, survival, invasion and metastasis. SDF-1, a major chemotactic factor, plays a key role in mediating cell trafficking via selective binding to CXCR4.

**Synonyms:** - CTCE 9908 - CTCE-9908 - CTCE-9908 - CTCE9908 - CXCR4 Antagonist CTCE-9908 - PTX 9908 - PTX-9908 - PTX9908 - SDF-1 Analog PTX-9908