Interleukin-15/Interleukin-15 Receptor Alpha Complex-Fc Fusion Protein XmAb24306

**Semantic type:** Pharmacologic Substance

**Definition:** An interleukin (IL)-15/IL-15-receptor alpha (IL-15Ra) complex fused to a bispecific Fc domain, with potential antineoplastic activity. Upon administration, XmAb24306 stimulates the proliferation of natural killer (NK) cells and memory CD8+ T-cells. The memory T-cells enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the immune response against tumor cells. This may increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates CD8+ T and NK cell development, activation and proliferation. XmAb24306 does not require endogenous IL-15Ra for its activation.

**Synonyms:** - IL15/IL15Ra Complex-Fc Fusion Protein XmAb24306 - IL15/IL15Ra-Fc Fusion Protein XmAb24306 - RO 7310729 - RO-7310729 - RO7310729 - XmAb 24306 - XmAb-24306 - XmAb24306