Anti-CD19 iCAR NK Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of natural killer (NK) cells engineered to express an inhibitory chimeric antigen receptor (iCAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19 iCAR-NK cells recognize, bind to and induce selective cytotoxicity in CD19-expressing tumor cells. The iCAR is designed to spare normal cells from NK cell actions by including an inhibitory receptor that is activated upon binding to antigens that are present on normal cells only. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.

**Synonyms:** - Anti-CD19 Inhibitory Chimeric Antigen Receptor-Natural Killer Cells - Anti-CD19 iCAR Natural Killer Cells - Anti-CD19 iCAR-NK Cells