Zifcasiran

**Semantic type:** Pharmacologic Substance

**Definition:** An RNA interference (RNAi) targeting hypoxia-inducible factor 2alpha (HIF-2a), with potential antineoplastic activity. Upon administration, zifcasiran binds to and neutralizes mRNA HIF2a, thereby preventing the production of HIF2a. This may lead to an inhibition of tumor cell proliferation. HIF2a, overexpressed in certain cell types, plays a key role in proliferation, progression and metastasis of tumors.

**Synonyms:** - ADS-007 - ARO HIF2 - ARO-HIF2 - AROHIF2 - HIF2a RNAi ARO-HIF2 - RNA Interference Therapeutic ARO-HIF2 - TRiM ARO-HIF2 - Targeted RNAi Molecule ARO-HIF2 - ZIFCASIRAN