Individualized MVA-based Vaccine TG4050

**Semantic type:** Immunologic Factor|Pharmacologic Substance

**Definition:** An off-the-shelf (OTS) individualized vaccine comprised of a modified Vaccinia virus Ankara (MVA) viral vector encoding tumor-specific neoantigens (TSNAs), with potential immunostimulatory and antineoplastic activities. Following administration of the individualized MVA-based vaccine TG4050, the neoantigens are expressed and presented to the immune system, which induces the activation of a specific cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing the patient-specific neoantigens.

**Synonyms:** - MVA-Neoantigen Vaccine TG4050 - Neoantigen-expressing MVA-based Vaccine TG4050 - TG 4050 - TG-4050 - TG4050 - TG4050 Vaccine