Lintuzumab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A humanized recombinant monoclonal antibody directed against CD33, a cell surface antigen found on myeloid leukemia blasts and early hematopoietic progenitor cells. Lintuzumab stimulates antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells expressing CD33, resulting in a decrease in tumor burden. The humanized version of this monoclonal antibody exhibits less immunogenicity and improved binding affinity compared to its murine counterpart.

**Synonyms:** - Hu-M195 monoclonal antibody - HuG1-M195 monoclonal antibody - Humanized M195 - LINTUZUMAB - MoAb HuG1-M195 - MoAb HuM195 - MoAb HuM195 - Monoclonal Antibody HuG1-M195 - Monoclonal Antibody HuM195 - SGN-33 - SMART M195 - Zamyl - lintuzumab - monoclonal antibody HuM195 HuG1-M195