DNA Topoisomerase 1 Cleavable Complex

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** A complex between the enzyme DNA topoisomerase 1 (TOP1) and its DNA substrate. Under normal conditions these complexes are transient and found at low levels. In the presence of therapeutic TOP1 inhibitors these complexes are stabilized, which prevents DNA religation and induces lethal DNA strand breaks.

**Synonyms:** - DNA Topoisomerase I Cleavable Complex - TOP1-DNA Intermediate - TOPI Cleavable Complex - Top1 Cleavable Complex - Topo I Cleavable Complex - Topoisomerase 1 Cleavable Complex - Topoisomerase I Cleavable Complex