Andexanet Alfa

**Semantic type:** Pharmacologic Substance

**Definition:** A genetically modified variant of human factor Xa (FXa) protein, that may be used to reverse the anticoagulation effect of direct oral FXa inhibitors. Upon intravenous administration, andexanet alfa binds to the administered FXa inhibitor, thereby neutralizing the anticoagulant effect of the FXa inhibitor. Andexanet alfa also binds to and inhibits the activity of tissue factor pathway inhibitor (TFPI), thereby increasing tissue factor (TF)-initiated thrombin generation and promoting coagulation.

**Synonyms:** - ANDEXANET ALFA - Andexanet alfa - Andexxa - Coagulation Factor Xa (Recombinant), Inactivated-zhzo - Factor Xa Recombinant Inactivated-zhzo - Ondexxya - PRT 4445 - PRT-4445 - PRT4445