Azoximer Bromide

**Semantic type:** Pharmacologic Substance

**Definition:** The bromide form of azoximer, a N-oxidized polyethylene-piperazine derivative and a heterochain aliphatic polyamine, with potential immunomodulating and immunoadjuvant activities. Upon administration, azoximer binds to and induces the activation of myeloid cells, mostly monocytes and neutrophils, and, to a lesser extent, lymphocytes. Azoximer increases the expansion of immature DC (iDC) and mature DC (mDC) at inflammatory sites, stimulates expression of several DC co-stimulatory molecules, and induces the proliferation and recruitment of T-cells to inflammatory or tumor sites. Azoximer also enhances intracellular hydrogen peroxide (H2O2) production.

**Synonyms:** - AZOXIMER BROMIDE - Polyoxidonium (TM)