Talquetamab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A bispecific humanized monoclonal antibody against human CD3, a T-cell surface antigen, and human G-protein coupled receptor family C group 5 member D (GPRC5D), a tumor-associated antigen (TAA), with potential antineoplastic activity. Upon administration, talquetamab binds to both CD3 on T-cells and GPRC5D expressed on certain tumor cells. This results in the cross-linking of T-cells and tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against GPRC5D-expressing tumor cells. GPRC5D is overexpressed on certain tumors, such as multiple myeloma, while minimally expressed on normal, healthy cells, and plays a key role in tumor cell proliferation.

**Synonyms:** - Anti-CD3/Anti-GPRC5D Bispecific Monoclonal Antibody JNJ-64407564 - GPRC5D x CD3 Bispecific Antibody JNJ-64407564 - GPRC5D x CD3 DuoBody Antibody JNJ-64407564 - GPRC5D/CD3 DuoBody Antibody JNJ-64407564 - Humanized GPRC5D x CD3 DuoBody Antibody JNJ-64407564 - JNJ 64407564 - JNJ-64407564 - JNJ64407564 - TALQUETAMAB - Talquetamab-tgvs