Elacestrant Hydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** The hydrochloride salt form of elacestrant, an orally available, selective estrogen receptor degrader (SERD), with antineoplastic activity. Upon oral administration, elacestrant acts as a SERD, which binds to the estrogen receptor (ER) and induces a conformational change that results in the proteosomal degradation of the receptor. This prevents ER-mediated signaling and inhibits proliferation of ER-expressing cancer cells.

**Synonyms:** - ELACESTRANT HYDROCHLORIDE - Orserdu - RAD-1901 Dihydrochloride - RAD1901 Dihydrochloride