Thymidylate Synthase

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Thymidylate synthetase protein (312 aa, ~36 kDa) is encoded by the human TYMS gene. The protein is a conserved transferase enzyme that catalyzes methylene tetrahydrofolate (MTHF)/dUMP conversion to dihydrofolate/dTMP in thymidine triphosphate/deoxyribonucleotide biosynthesis. Thymidylate synthetase competes with the methylene tetrahydrofolate receptor for MTHF and maintains the dTMP pool for DNA replication and repair.

**Synonyms:** - EC 2.1.1.45 - TMP synthetase - TS - TSase - TYMS - Thymidylate Synthetase - dTMP Synthase - thymidylate synthase