Cord Blood Derived CAR T-Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of umbilical cord blood (CB)-derived T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) that targets an as of yet unidentified tumor-associated antigen (TAA), with potential immunomodulatory and antineoplastic activities. Upon administration of the cord blood derived CAR T-cells, the T-cells target, bind to and induce selective cytotoxicity in tumor cells expressing the TAA.

**Synonyms:** - CB Derived CAR T-Cells - Cord Blood CAR T-Cells