Drug Accumulation Index

**Semantic type:** Intellectual Product

**Definition:** An index reflecting the extent of drug accumulation in the body. It is usually expressed as the ratio of the area under a plasma concentration-time curve (AUC) during a dosage interval at steady state compared to the AUC of a dosage interval after the first dose. It is affected by rate of dose administration, bioavailability, and clearance.

**Synonyms:** - RAC