Cetuximab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A recombinant, chimeric monoclonal antibody directed against the epidermal growth factor (EGFR) with antineoplastic activity. Cetuximab binds to the extracellular domain of the EGFR, thereby preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization may result in an inhibition in signal transduction and anti-proliferative effects. This agent may inhibit EGFR-dependent primary tumor growth and metastasis. EGFR is overexpressed on the cell surfaces of various solid tumors.

**Synonyms:** - C 225 - C-225 - C225 - CETUXIMAB - Cetuximab Biosimilar CDP-1 - Cetuximab Biosimilar CMAB009 - Cetuximab Biosimilar KL 140 - Chimeric Anti-EGFR Monoclonal Antibody - Chimeric MoAb C225 - Chimeric Monoclonal Antibody C225 - Erbitux - Erbitux - IMC-C225 - cetuximab