Lucinactant

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic pulmonary surfactant composed of sinapultide (KL4 peptide), phospholipids, including dipalmitoylphosphatidylcholine (DPPC) and palmitoyloleoyl phosphatidylglycerol (POPG), and palmitic acid, with surfactant activity. Upon administration, lucinactant mimics endogenous pulmonary surfactant and lines the alveoli and smallest bronchioles, thereby keeping alveoli open during expiration by lowering surface tension. This improves lung function, respiratory gas exchange and oxygenation.

**Synonyms:** - API 02 - ATI 02 - KL4-surfactant - LUCINACTANT - Surfaxin