Phosphatidylinositol-4,5-Bisphosphate 3-Kinase

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** An enzyme that catalyzes the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate. This is the first committed step in the biosynthesis of phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. This pathway is thought to play a critical role in DNA repair, V(D)J recombination and cell cycle checkpoints. (from LocusLink)

**Synonyms:** - 1-Phosphatidylinositol 3-Kinase - EC 2.7.1.153 - PI 3 Kinase - PI3 Kinase - PI3 kinase - PI3-Kinase - PI3K - Phosphatidylinositide 3-Kinase - Phosphatidylinositol 3 Kinase - Phosphatidylinositol 3-Kinase - Phosphatidylinositol-3-Kinase - Type I Phosphatidylinositol Kinase - Type III Phosphoinositide 3-Kinase - phosphatidylinositol-3 kinase