Genetically Modified SARS-CoV-2 Spike Protein-encoding Bifidobacterium longum DNA Vaccine

**Semantic type:** Immunologic Factor|Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A live, genetically modified probiotic bacteria Bifidobacterium longum (B. longum) engineered to deliver plasmids containing synthetic DNA encoding SARS-CoV-2 spike (S) protein, with potential immunizing activity against SARS-CoV-2. Upon oral administration of genetically modified SARS-CoV-2 S protein-encoding B. longum DNA vaccine, the bacteria colonize the gut, bind to intestinal epithelial cells, replicate and deliver plasmids containing synthetic DNA encoding the SARS-CoV-2 S protein, and the cells produce the SARS-CoV-2 S protein. This may activate both humoral and cellular immune responses which may result in protection against SARS-CoV-2 infection.

**Synonyms:** - Genetically Modified SARS-CoV-2 S Protein-encoding Bifidobacterium longum DNA Vaccine - bacTRL-Spike