Obecabtagene Autoleucel

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a second-generation chimeric antigen receptor (CAR), CAT-41BBz CAR, targeting the tumor-associated antigen (TAA) CD19, with immunostimulating and antineoplastic activities. Upon administration, obecabtagene autoleucel target and bind to CD19-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells and tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. The CAT-41BBz CAR has a faster off-rate compared with FMC63-41BBz CAR. This may minimize cytokine release and reduce toxicities, and enhance persistence of the CAR T-cells.

**Synonyms:** - AUTO 1 - AUTO-1 - AUTO1 - AUTO1 CAR-T Cells - Aucatzyl - Autologous Anti-CD19 CAR T-cells AUTO1 - Autologous Anti-CD19 Chimeric Antigen Receptor T-cells AUTO1 - Autologous Anti-CD19 Chimeric Antigen Receptor T-lymphocytes AUTO1 - Autologous CD19-targeted CAR T-cells AUTO1 - CD19CAR T-cells AUTO1 - CD19CAT-41BBZ CAR T-cells AUTO1 - OBECABTAGENE AUTOLEUCEL - Obe-cel