Celecoxib

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A nonsteroidal anti-inflammatory drug (NSAID) with a diaryl-substituted pyrazole structure. Celecoxib selectively inhibits cyclo-oxygenase-2 activity (COX-2); COX-2 inhibition may result in apoptosis and a reduction in tumor angiogenesis and metastasis.

**Synonyms:** - 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide - Benzenesulfonamide, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]- - CELECOXIB - CELECOXIB - Celebrex - Elyxyb - Onsenal - SC-58635 - YM 177 - celecoxib