Posoleucel

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A population of closely human leukocyte antigen (HLA)-matched, off-the-shelf (OTS), donor-derived cytotoxic T lymphocytes (CTLs) that are specifically reactive towards six viruses, Epstein-Barr virus (EBV), cytomegalovirus (CMV), adenovirus (AdV), human herpesvirus 6 (HHV6; HHV-6), human polyomavirus type I (BKV) and human polyomavirus type II (JC virus; JCV), with potential antiviral activity. Upon infusion into allogeneic hematopoietic stem cell transplant (HSCT) recipients and immunocompromised patients, posoleucel provides virus-specific cellular immunity and causes specific anti-viral effects against active viral infections. This may prevent EBV, CMV, AdV, HHV6, BKV and JCV reactivation and infection, and inhibits viral-associated diseases.

**Synonyms:** - ALVR 105 - ALVR-105 - ALVR105 - Allogeneic EBV/CMV/AdV/HHV6/BKV/JCV-specific CTLs ALVR105 - Allogeneic Multi-virus-specific CTLs ALVR105 - POSOLEUCEL - VSTs ALVR105 - Viralym-M