Covid-19 aAPC Vaccine

**Semantic type:** Cell|Immunologic Factor|Pharmacologic Substance

**Definition:** A vaccine composed of artificial antigen presenting cells (aAPCs) that have been lentivirally transduced with synthetic minigenes that have been engineered based on conserved domains of selected severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) viral structural proteins and immune modulatory genes, with potential immunizing and anti-viral activities. Upon subcutaneous administration of the Covid-19 aAPC vaccine, the viral proteins and immune modulatory genes are expressed and may activate the immune system to elicit a specific cytotoxic T-cell (CTL) response against the SARS-CoV-2 viral antigens encoded by the minigenes.

**Synonyms:** - Covid-19 Artificial Antigen Presenting Cell Vaccine - Covid-19/aAPC Vaccine