Ad5-nCoV COVID-19 Vaccine

**Semantic type:** Cell|Immunologic Factor|Pharmacologic Substance

**Definition:** A recombinant, replication-deficient coronavirus vaccine composed of a genetically engineered adenovirus type 5 (Ad5) vector that expresses full-length SARS-CoV-2 spike protein (SP), with potential immunomodulating and anti-COVID-19 activities. Upon intramuscular administration of the Ad5-nCoV vaccine, the Ad5 infects human cells, which produce the SARS-CoV-2 SP, and travel to the lymph nodes where the immune system creates anti-SARS-CoV-2 SP antibodies. The antibodies recognize the SP and kill SARS-CoV-2. This prevents SARS-CoV-2 infection. SP, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus.

**Synonyms:** - Ad5-encoding SARS-CoV-2 Spike Protein Vaccine - Ad5-nCoV COVID-19 - Adenovirus Type 5-encoding SARS-CoV-2 Spike Protein