ChAdOx1 nCoV-19 Vaccine

**Semantic type:** Immunologic Factor|Pharmacologic Substance|Virus

**Definition:** A vaccine composed of a replication-deficient chimpanzee adenovirus, ChAdOx1, encoding the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (SP), with potential immunomodulating and anti-viral activities. Upon administration, ChAdOx1 nCoV-19 expresses the SARS-CoV-2 SP, which induces a humoral and cell-mediated immune response against SARS-CoV-2. This may prevent SARS-CoV-2 infection and inhibit viral replication. SP, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus.

**Synonyms:** - AZD 1222 - AZD-1222 - AZD-1222 - AZD1222 - AZD1222 SARS-CoV-2 Vaccine - AstraZeneca COVID-19 Vaccine - ChAdOx1 nCoV-19 - ChAdOx1-S - Covishield - Oxford-Astrazeneca Covid Vaccine - SARS-CoV-2 Vaccine AZD1222 - Vaxzevria