Crisponi/Cold-Induced Sweating Syndrome-2

**Semantic type:** Disease or Syndrome

**Definition:** An autosomal recessive condition caused by mutation(s) in the CLCF1 gene, encoding cardiotrophin-like cytokine factor 1. It is characterized by cold-induced sweating syndrome, dysmorphic features, poor sucking reflex, and temperature spikes presenting at infancy. It is clinically indistinguishable from Crisponi/cold-induced sweating syndrome-1.

**Synonyms:** - CISS2