Ficerafusp Alfa

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A bifunctional monoclonal antibody targeting both the receptor tyrosine kinase epidermal growth factor receptor (EGFR) and the pro-inflammatory cytokine human transforming growth factor beta (TGF-beta; TGFb), with potential antineoplastic activity. Upon administration of ficerafusp alfa, the anti-EGFR moiety targets, binds to and prevents activation of EGFR-mediated signaling. This leads to an inhibition of EGFR-dependent downstream pathways and EGFR-dependent tumor cell proliferation and metastasis. The anti-TGFb moiety targets and binds to TGFb, thereby preventing the activation of TGFb-mediated signaling pathways. This may inhibit the proliferation of tumor cells in which TGFb is overactivated. EGFR and TGFb, mutated and/or overexpressed on the surfaces of various tumor cell types, play key roles in tumor cell proliferation and progression.

**Synonyms:** - Anti-EGFR/TGFb Bispecific Monoclonal Antibody BCA101 - Anti-EGFR/TGFb Monoclonal Antibody BCA101 - BCA 101 - BCA-101 - BCA101 - EGFR/TGFb Fusion Monoclonal Antibody BCA101 - FICERAFUSP ALFA - FMAB2