ERCC8 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human ERCC8 wild-type allele is located in the vicinity of 5q12.1 and is approximately 71 kb in length. This allele, which encodes DNA excision repair protein ERCC-8, is involved in transcription-coupled nucleotide excision repair. Mutation of the gene is associated with Cockayne syndrome A and UV-sensitive syndrome 2.

**Synonyms:** - CKN1 - CSA - Cockayne Syndrome 1 (Classical) Gene - ERCC Excision Repair 8, CSA Ubiquitin Ligase Complex Subunit wt Allele - Excision Repair Cross-Complementation Group 8 Gene - Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 Gene - Excision Repair Cross-Complementing, Group 8 Gene - UVSS2