Masofaniten

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable, second-generation inhibitor of the N-terminal domain (NTD) of androgen receptor (AR), with potential antineoplastic activity. Upon oral administration, masofaniten specifically binds to the NTD of AR, thereby inhibiting both AR activation and the AR-mediated signaling pathway. This may inhibit cell growth in AR-overexpressing tumor cells. AR is overexpressed in prostate cancers and is involved in the proliferation, survival and chemoresistance of tumor cells. Masofaniten may be more active and metabolically stable than first-generation AR NTD inhibitors.

**Synonyms:** - AR Inhibitor EPI-7386 - Androgen Receptor Inhibitor EPI-7386 - EPI 7386 - EPI-7386 - EPI7386 - MASOFANITEN - Methanesulfonamide, N-(4-((4-(1-(3-chloro-4-(2-chloroethoxy)-5-cyanophenyl)-1-methylethyl)phenoxy)methyl)-2-pyrimidinyl)- - N-(4-((4-(2-(3-Chloro-4-(2-chloroethoxy)-5-cyanophenyl)propan-2-yl)phenoxy)methyl)pyrimidin-2-yl)methanesulfonamide