Autologous AFP Specific T Cell Receptor Transduced T Cells C-TCR055

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of human autologous T-lymphocytes transduced with a lentiviral vector encoding for a T-cell receptor (TCR) recognizing the human leukocyte antigen (HLA)-A*02:01 restricted human alpha-fetoprotein (AFP) 158-166 peptide (FMNKFIYEI), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the AFP specific TCR transduced T cells recognize and bind to AFP antigen-positive cells, which results in lysis and killing of AFP-positive cancer cells. AFP is overexpressed in a variety of cancers while its expression is restricted in normal tissues.

**Synonyms:** - Autologous AFP-specific TCR-transduced T-cells C-TCR055 - C-TCR 055 - C-TCR-055 - C-TCR055