Activating KRAS Exon 4 Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of exon 4 of the KRAS gene that results in constitutive activation of both GTPase KRas protein and its downstream signaling pathways.

**Synonyms:** - Activating KRAS Exon 4 Gene Mutation - Activating KRAS-2 Exon 4 Mutation - Activating KRAS2 Exon 4 Mutation - Activating c-K-ras Exon 4 Mutation - Activating v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog Exon 4 Mutation - KRAS Exon 4 Activating Gene Mutation - KRAS Exon 4 Activating Mutation