Tumor Suppressor Gene

**Semantic type:** Gene or Genome

**Definition:** Tumor Suppressor Genes encode proteins whose functions inhibit expression of tumorigenic phenotypes by holding cellular proliferation in check. When inactivated or lost, a barrier to normal proliferation is removed and deregulated growth is possible. (NCI)

**Synonyms:** - Anti-Oncogene - Antioncogene - Tumor Suppressor - Tumor Suppressors - antioncogene - tumor suppressor gene