Engineered Toxin Body Targeting CD38 MT-0169

**Semantic type:** Pharmacologic Substance

**Definition:** An engineered toxin body (ETB) containing a single chain variable fragment (scFv) from an antibody targeting the cell surface glycoprotein ADP-ribosyl cyclase 1 (CD38) that is fused to a cytotoxic payload composed of the enzymatically active, de-immunized, ribosome-inactivating cytotoxic payload Shiga-like toxin-A subunit (SLTA), with potential antineoplastic activity. Upon administration of ETB targeting CD38 MT-0169, the anti-CD38 scFv moiety specifically targets and binds to CD38-expressing tumor cells. Upon internalization, the SLTA moiety is released and acts as an N-glycosidase, which binds to and removes an adenine nucleobase from the 28S RNA component of the 60S ribosomal subunit of ribosomes. This irreversibly inhibits ribosome activity, which inhibits protein synthesis and leads to apoptosis in CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies; its expression has been correlated with poor prognosis.

**Synonyms:** - CD38-targeted ETB TAK-169 - ETB Targeting CD38 MT-0169 - ETB Targeting CD38 TAK-169 - Engineered Toxin Body Targeting CD38 TAK-169 - MT 0169 - MT-0169 - MT0169 - TAK 169 - TAK-169 - TAK169