Anti-GPC3-CAR T-lymphocytes TAK-102

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-CAR T-lymphocytes TAK-102 specifically targets and binds to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation.

**Synonyms:** - Anti-GPC3 CAR T Cells TAK-102 - CAR T Cells TAK-102 - Glypican-3-specific CAR T Cells TAK-102 - TAK 102 - TAK-102 - TAK102