HPV6/11-targeted DNA Plasmid Vaccine INO-3107

**Semantic type:** Immunologic Factor|Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A DNA vaccine consisting of plasmids encoding E6 and E7 genes of human papilloma virus subtype 6 (HPV-6) and 11 (HPV-11), with potential immunostimulating and antineoplastic activities. Upon administration via intramuscular electroporation, the HPV-6/11-targeted DNA plasmid vaccine INO-3107 expresses the HPV-6/11 E6 and E7 proteins, which may elicit a cytotoxic T-lymphocyte (CTL) response against tumor cells that are expressing HPV6 and/or HPV11 E6 and E7 proteins, resulting in tumor cell lysis. HPV-6/11 infections are associated with aerodigestive malignancies.

**Synonyms:** - HPV-6/11-targeting Immunotherapeutic Vaccine INO-3107 - HPV6/11-targeted DNA Plasmid Immunotherapeutic INO-3107 - INO 3107 - INO-3107 - INO3107