NF-kB

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor

**Definition:** NF-kB is a heterodimer complex of two DNA-binding subunits from two families of ubiquitous, inducible, nuclear transcription activators involved in cytokine-induced activation of gene expression. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-kB complex. NF-kB is inhibited by IkB proteins (NFKBIA or NFKBIB), which inactivate NF-kB by trapping it in the cytoplasm. Phosphorylation of IkB by kinases (IKBKA or IKBKB) marks them for ubiquitination, allowing NF-kB translocation to the nucleus and DNA binding at kappa-B transcription enhancer motifs. In B-lymphocytes, NF-kB binds to the immunoglobulin kappa light chain enhancer and in T-lymphocytes it binds to enhancers in virally infected cells, including HIV. (from OMIM 164011, 164012, 164910, 164014, 604758, and NCI)

**Synonyms:** - NF-Kappa B - NF-Kappa-B - NF-KappaB - NFKB - NFkappaB - Nuclear Factor Kappa B - Nuclear Factor Kappa-B - Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells - Nuclear Factor NF-Kappa-B - Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells - Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells - Nuclear Transcription Factor NF-kB