Recombinant Spike-protein Receptor-binding Domain-dimer SARS-CoV-2 Vaccine

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A recombinant protein-based vaccine composed of a recombinant spike (S) protein receptor-binding domain (RBD)-dimer, produced in Chinese hamster ovary (CHO) cells, of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), with potential immunomodulating and anti-coronavirus disease 2019 (COVID-19) activities. Upon intramuscular administration of the recombinant S-protein RBD-dimer SARS-CoV-2 vaccine, the S protein RBD-dimer activates the immune system to create anti-SARS-CoV-2 S protein antibodies. The antibodies recognize and neutralize the S protein and kill SARS-CoV-2. This prevents SARS-CoV-2 infection. S-protein, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus. The dimeric form of SARS-CoV-2 RBD may increase its immunogenicity.

**Synonyms:** - Recombinant S-protein RBD-dimer SARS-CoV-2 Vaccine - Recombinant Spike-protein RBD-dimer Coronavirus Vaccine