Activating KIT Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the KIT gene that results in constitutive activation of both mast/stem cell growth factor receptor Kit and its downstream signaling pathways.

**Synonyms:** - Activating C-KIT Mutation - Activating CD117 Gene Mutation - Activating KIT Mutation - Activating KIT Proto-Oncogene Tyrosine Protein Kinase Gene Mutation - Activating c-KIT Gene Mutation - Activating v-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog Gene Mutation - KIT Activating Mutation