TM4SF1-CAR/EpCAM-CAR-expressing Autologous T Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A mixed preparation of allogeneic T-lymphocytes that have been genetically modified to express either a chimeric antigen receptor (CAR) specific for the antigen transmembrane 4 L six family member 1 (TM4SF1) (CART-TM4SF1) or a CAR specific for epithelial cell adhesion molecule (EpCAM) (CART-EpCAM), with potential immunostimulating and antineoplastic activities. Upon administration of the TM4SF1-CAR/EpCAM-CAR-expressing autologous T cells, the TM4SF1-CAR-expressing autologous T-cells specifically recognize and bind to TM4SF1-expressing tumor cells and the EpCAM-CAR-expressing autologous T-cells specifically recognize and bind to EpCAM-expressing tumor cells, resulting in tumor cell lysis. TM4SF1 and EpCAM are expressed by a variety of tumor cells.

**Synonyms:** - Autologous CART-TM4SF1 Cells/CART-EpCAM Cells - Autologous TM4SF1-targeting CAR T-cells and EpCAM-targeting CAR T-cells - TM4SF1-CAR Autologous T-cells/EpCAM-CAR Autologous T-cells