Vopikitug

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A monoclonal antibody against CD25 (IL-2R alpha), with potential antineoplastic activity. Upon administration, vopikitug targets and binds to CD25 expressed on tumor-infiltrating regulatory T (Treg) cells. This may deplete Treg cells and prevent immunosuppression, thereby enhancing anti-tumor immune responses. CD25, the alpha chain of the interleukin (IL)-2 receptor, is highly expressed on Treg cells but not on effector T (Teff) cells in tumors.

**Synonyms:** - Anti-CD25 Monoclonal Antibody RG6292 - Anti-CD25 Monoclonal Antibody RO7296682 - RG 6292 - RG-6292 - RG6292 - RO 7296682 - RO-7296682 - RO7296682 - T-regulatory Cell-depleting Antibody RO7296682 - VOPIKITUG