Imlunestrant

**Semantic type:** Pharmacologic Substance

**Definition:** An orally available selective estrogen receptor degrader (SERD), with potential antineoplastic activity. Upon oral administration, imlunestrant specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that results in ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells. Imlunestrant is able to cross the blood-brain barrier (BBB).

**Synonyms:** - IMLUNESTRANT - LY 3484356 - LY-3484356 - LY3484356 - SERD LY3484356 - Selective Estrogen Receptor Degrader LY3484356